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Aspirin acts by irreversibly inhibiting cyclooxygenase-1 and 2 (COX-1 and 2) enzymes, which also results in decreased formation of prostaglandins.

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It's time to do something about that discomfort and inflammation.

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In another nonlimiting embodiment, the topical diclofenac is a gel formulation comprising diclofenac sodium, dimethyl sulfoxide, ethanol, propylene glycol, one or more thickening agents, and water.

There were fewer ulcer complications in the celecoxib group compared with the NSAID group, both in patients taking concomitant aspirin and those not taking aspirin, but the difference reached statistical significance only in the latter comparison.

If clinical signs and symptoms consistent with liver disease develop, or if systemic manifestations occur (e.

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Although acetaminophen was associated with fewer GI adverse effects than were nonselective NSAIDs, the risk of any adverse GI event was similar between celecoxib and acetaminophen in two systematic reviews.

Take 1 tablet daily (with food) when required to relieve pain and inflammation.

Hepatic metabolism accounts for almost 100% of diclofenac elimination.

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Administer the separate products of misoprostol and diclofenac if a higher dose of diclofenac is deemed necessary.

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Diclofenac was first synthesized by Alfred Sallmann and Rudolf Pfister and introduced as Voltaren by Ciba-Geigy (now ) in 1973.

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