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Regulation of pyruvate dehydrogenase activity and citric acid cycle intermediates during high cardiac power generation.

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Silent myocardial ischemia: Prognosis and therapy.

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The role of Hes genes in intestinal development, homeostasis and tumor formation.

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However, the consistency and persistence of the incremental benefit from PCI with respect to angina make it less likely that a placebo effect could fully explain the observed differences, and it would not explain the substantial improvement in the medical-therapy group.

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E-4031 (60 nM) and dronedarone (6 μM); F: E-4031 (60 nM) and dronedarone (10 μM); G: E-4031 (60 nM), dronedarone (10 μM), and ranolazine (6-10 μM).

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Little data available on high doses, long exposure, use with QT interval-prolonging drugs, or potassium channel variants causing prolonged QT interval.

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Myocardial ischaemia and hypoxia in SCAD are caused by a transient imbalance between blood supply and metabolic demand.

Aspirin is the first-line antiplatelet drug, unless the patient has aspirin allergy or a history of or risk for gastrointestinal bleeding.

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Alberta Provincial Project for Outcome Assessment in Coronary Heart Disease (APPROACH) Investigators.

Differential modulation of citrate synthesis and release by fatty acids in perfused working rat hearts.

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The recommendations for formulating and issuing ESC Guidelines can be found on the ESC website ().

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The incidence of left main disease is roughly 5-10%.

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The ROLE (Ranolazine Open Label Experience) program included 746 patients who completed the MARISA and CARISA trials and consented to participate in an open-label, 6-year follow-on extension.

Ranolazine is used to prevent angina attacks.

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Protective effects of ranolazine in guinea-pig hearts during low-flow ischemia and their association with increases in active pyruvate dehydrogenase.

It will be understood, however, that the amount of each active agent actually administered will be determined by a physician, in the light of the relevant circumstances, including the condition to be treated, the chosen route of administration, the actual compounds administered and their relative activity, the age, weight, and response of the individual patient, the severity of the patient's symptoms, and the like.

For example, the combination of dronedarone and ranolazine has synergism in reducing AV nodal conduction and ventricular tachyarrhythmia.

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Be sure to mention any of the following: amiodarone (Cordarone, Nexterone, Pacerone); antidepressants such as amitriptyline, clomipramine (Anafranil), and desipramine (Norpramin); and imipramine (Tofranil); medications to treat high cholesterol such as atorvastatin (Lipitor, in Caduet), lovastatin (Altoprev, in Advicor), and simvastatin (Zocor, in Simcor, in Vytorin); cyclosporine (Gengraf, Neoral, Sandimmune); digoxin (Lanoxin); diltiazem (Cardizem, Dilacor, Tiazac, others); dofetilide; (Tikosyn); erythromycin (E.

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Analyses according to the treatment initially received also showed little effect on the differences between groups.

Furthermore, ranolazine reduced the focal ECM degradative activity of shCTL cells by 58.

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In all other ways it is the same medicine with the same active ingredients, identical in use, safety, strength and all other characteristics.

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In one embodiment, the oral dose of ranolazine is administered about 1 hour prior to the termination of the intravenous infusion of ranolazine.

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The findings indicate that a combination of dronedarone and ranolazine is more effective to prevent the induction of TdP ventricular tachycardia than is dronedarone alone.

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A generic drug is actually its brand-name equivalent, although it doesnt bear the original trademark and looks slightly different.

Instead, the patient must meet the health care team at least halfway to achieve a successful health outcome.

Together, these data suggest ranolazine slowly stabilizes fast inactivation by interacting with Na V channel fast-inactivated states.

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Panel A: ranolazine caused a similar relative increase in MAPD 90 in the absence and presence of dronedarone (0.

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Left ventricular end-diastolic pressure and pulmonary capillary wedge pressure decreased in the ranolazine group, but not in the placebo group.

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Because of the high prevalence of silent ischaemic episodes and possible arrhythmias, 24-hour ambulatory ECG monitoring can be used to verify the treatment efficiency.

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After oral administration of ranolazine as a solution, 73% of the dose is systemically available as ranolazine or metabolites.

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